Case of Double Multiple Exostoses

A Case of Multiple Unilateral Exostoses

Multiple cartilage-tipped osteomata are often congenital, hereditary, and fairly symmetrically bilateral. They occur near the growing ends of long bones in the vicinity of the epiphyseal cartilage; this gives strong support to the view that they arise in a sequestrated part, or ' rest', of the epiphyseal cartilage. They may therefore be common in cases where present or previous rickets have cau...

Hereditary multiple exostoses: A case-report.

Severe Multiple Cartilaginous Exostoses

Multiple cartilaginous exostoses (MCE) is one of the most common inherited skeletal disorders. A collection of 1124 cases was reported by Stock and Barrington (1925). Recently other large series have been published by Solomon (1963) and Sauer (1979). Different terms have been used for it such as multiple exostoses, hereditary multiple exostoses and diaphyseal aclasis. The swelling or "lump" are...

Hereditary multiple exostoses.

Hereditary multiple exostoses (HME) is a skeletal disorder which primarily affects enchondral bone during growth. It is characterised by multiple exostoses, usually arising in the juxtaepiphyseal region of the long bones. Exostoses that affect "almost every bone in the body" were first mentioned by John Hunter in his Lectures on the principles of surgery in 1786.1 The first family affected by H...

Manifestations of hereditary multiple exostoses.

The solitary osteochondroma, a common pediatric bone tumor, is a cartilage-capped exostosis. Hereditary multiple exostosis is an autosomal dominant disorder manifested by the presence of multiple osteochondromas. Linkage analysis has implicated mutations in the EXT gene family, resulting in an error in the regulation of normal chondrocyte proliferation and maturation that leads to abnormal bone...